Botanical compounds, that we call cPACs exist in nature and having been patented by UroPharma for #urinarytract use, are being investigated by the company. They are for incorporation into a #lubricant urethral gel for safer urinary catheterisation, because the first line of defence against CAUTI is to prevent the bacteria getting into the bladder in the first place! #Urinary #catheters are such essential clinical tools that over a billion units are used annually with numbers

The distal urethra is a residency for #bacteria, mostly commensals, but sometimes potential uropathogens move in. #Catheterisation hygiene cleans the skin around the urethral meatus but does not remove bacteria residing in the distal urethra. Many people have focused time, effort and money on coatings that are supposed to prevent such bacteria surviving #catheter entry into the #bladder. Such a #coating would need to kill the potential pathogens before they are transferred fr