During much of my medical career, my understanding of the human bladder was that it was a reservoir for the body’s metabolic waste and that it simply stores #urine until it signals a sense of fullness to motivate volitional voiding. As filling increases tissue distension, intensity of desire to void increases accordingly. Throughout most of the day, the bladder just passively fills. How reassuringly simple! I also understood that bladders, and mostly of females, are very vu

Historically, #cystitis generally was a problem for women, who otherwise were well. They suffered in silence, drank water like fish, and, perhaps, also guzzled K+ citrate and/or cranberry juice, for what they thought they were worth. Antibiotics’ arrival brought simple and convenient “pill-popping,” treatment with most getting symptom relief, while the others continued suffering quietly, so cystitis garnered little medico-scientific interest. Today, cystitis presents very d

Botanical compounds, that we call cPACs exist in nature and having been patented by UroPharma for #urinarytract use, are being investigated by the company. They are for incorporation into a #lubricant urethral gel for safer urinary catheterisation, because the first line of defence against CAUTI is to prevent the bacteria getting into the bladder in the first place! #Urinary #catheters are such essential clinical tools that over a billion units are used annually with numbers

From our CMO Professor Scott Glickman Colleagues: In medical and surgical services spanning primary through intensive care, we are dogged by UTI with their acute and long-term complications: treatment failures, recurrences, urosepsis, antimicrobial resistance (AMR) and high costs. Despite continuous improvements in antibiotic stewardship, these problems show little sign of abating. Something else must be involved. Antibiotic overuse and misuse shouldn’t be blamed exclusively