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86% nocturia reduction in Direct-to-Bladder clinical trial.

This research by Dr Luna-Rivera is one of many pieces of evidence that Direct-to-Bladder therapies can produce better outcomes than taking the drug orally.

The most notable parts in this article are:

  • Nocturia (passing urine in the night) decreased after 10 doses of bladder instillation.

  • Urinary urgency reduced by 86%.

  • Oral antimuscarinics are the first line of treatment but not always effective, …and have been associated with adverse effects that limit their use.

  • This clinical trial show almost no presence of undesirable side effects, in addition to a notable improvement in quality-of-life.


Luna Rivera et al
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