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The mess of UTI treatments


Colleagues: UTI finally is getting traction with the public. I saw a segment a few minutes ago on #ITV’s #GoodMorningBritain with actress #CherryHealey describing her heart-wrenching history and #urologist Jean MacDonald offering some mixed information. Incoming calls from the public also presented horror stories of e.g. 7x #UTI episodes since the new year. It’s obvious that, as yet our profession simply hasn’t come to grips with this scourge and its challenges. It’s time to ask why - and then how - we’re getting it wrong, stop blanket blaming patients for poor hygiene and look afresh at the issues. UTI therapeutics is wanting and is causing mayhem in the community, and in hospitals through #CAUTI.


My followers know that I’ve done a root cause analysis of the flaws in our treatments following the oral route of administration of #antibiotics, only to find the whole approach flawed but explicable and through our failure to follow fundamental pharmacological principles with our treatments.

 

I was dismayed to hear Cherry Healey talk about consuming #cranberry juice, and Jean implying it can help because it alters urinary pH. Actually, cranberry proanthocyanadins (flavonoids in the berry juice) entrap and effectively agglutinate bacteria. Unfortunately, most of them, as high-number polymers are too big to be absorbed from the gut, so don’t get to the bacteria in the bladder!


 

She, rightly, raised the issue about non-antibiotic treatments being unavailable. We have several potential candidates, but aren’t allowed to use them properly, yet. There’s so much more to this story!!! We are capable of turning the tide, because nature already provides us with several tools. We just need the regulators to allow us to use them effectively and efficiently under licence.

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