During much of my medical career, my understanding of the human bladder was that it was a reservoir for the body’s metabolic waste and that it simply stores #urine until it signals a sense of fullness to motivate volitional voiding. As filling increases tissue distension, intensity of desire to void increases accordingly. Throughout most of the day, the bladder just passively fills. How reassuringly simple! I also understood that bladders, and mostly of females, are very vu

Following on from revelations that we have a complex symbiotic relationship with our #gut microbiome, the discovery that we also have a #urobiome has attracted much attention. There’s no going back to believing the urinary #bladder is sterile. Thank you, Alan #Wolfe. Studies showing differences between normal and diseased bladder urobiomes raise questions about their influences on bladder health and disease aetiology, especially regarding #inflammatory and #pain syndromes,