During much of my medical career, my understanding of the human bladder was that it was a reservoir for the body’s metabolic waste and that it simply stores #urine until it signals a sense of fullness to motivate volitional voiding. As filling increases tissue distension, intensity of desire to void increases accordingly. Throughout most of the day, the bladder just passively fills. How reassuringly simple! I also understood that bladders, and mostly of females, are very vu

My late friend, mentor and former UCL professor of medicine James Malone-Lee advised that a good clinician does the right things very well for patients, but a medical academic is charged to determine, through research, what the right things are to do. We both sought to determine the “right way” to treat bladder infections because he, as a geriatrician, and I, as a neurorehabilitation doctor treating people with CNS diseases such as #MS, saw so many routinely. James believed

Colleagues, I am pleased to inform you that UroPharma has successfully completed another major step on the road to bringing our...

Colleagues: UTI finally is getting traction with the public. I saw a segment a few minutes ago on #ITV’s #GoodMorningBritain with actress...

I offer this “case report” and cautionary note to dedicated doctors with inventive minds. For many years in UK medicine, the most...

For some reason, we long assumed that #bacteria in the extra-systemic, #urinary cavity are subject to the same conditions as in other tissue infections, but they aren’t. #Antibiotics get to other tissue infections via blood whereas #cystitis #pathogens encounter antibiotics in #urine. That’s a big difference, first of all, blood pH range is narrow, so an antibiotic’s MIC (minimum inhibitory concentration) is predictable there. The urinary pH range is very wide. Antibiotic MIC

When we find a solution to a problem, naturally we look to the same approach for the next similar challenge. #Antibiotics changed the...

The distal urethra is a residency for #bacteria, mostly commensals, but sometimes potential uropathogens move in. #Catheterisation hygiene cleans the skin around the urethral meatus but does not remove bacteria residing in the distal urethra. Many people have focused time, effort and money on coatings that are supposed to prevent such bacteria surviving #catheter entry into the #bladder. Such a #coating would need to kill the potential pathogens before they are transferred fr

Homeostatic mechanisms optimise our cellular chemistry. #antibiotics treatments are developed specifically to work in our narrow-band homeostatic chemical milieu to be delivered through blood to #infection sites for intimate combat with #bacterial invaders. With #cystitis, the bacteria are planktonic in urine and attached to urothelial cell membranes, so are too far away to be influenced by that approach. For #antibiotic tablets to have any chance to be effective against cy

From our CMO Professor Scott Glickman Colleagues: In medical and surgical services spanning primary through intensive care, we are dogged by UTI with their acute and long-term complications: treatment failures, recurrences, urosepsis, antimicrobial resistance (AMR) and high costs. Despite continuous improvements in antibiotic stewardship, these problems show little sign of abating. Something else must be involved. Antibiotic overuse and misuse shouldn’t be blamed exclusively