top of page

For clinician’s treating #urinary #urgency and their patients

This page from European Urology is enlightening for anyone treating urinary urgency or taking the treatments. The text explains that oral treatments’ beneficial responses are slight, modest and substantially placebo effects at the cost of over twice the risk of inducing cognitive impairments.


They also produce symptomatic side effects, most notably dry mouth, that are real and mechanistically well understood as antimuscarinic actions on tissue receptors.


The authors explain that any benefits arise through actions on bladder mucosa.


If the drugs were instilled into the bladder directly, then the benefits should be achieved without producing symptomatic or adverse side effects, such as unquenchable dry mouth thirst, because of their limited systemic absorption through urothelium.


I wonder how many elderly people have been transferred into nursing care because we treat urinary urgency with tablets.


It is time we all seriously consider direct-target treatment for bladder diseases and disorders such as urinary urgency. The sooner such products are available under licence, the better.


Side effects from overactive bladder treatments
.pdf
Download PDF • 177KB

5 views0 comments

Recent Posts

See All

The new UK anti-AMR strategy plan

Colleagues I’ve been wading through the UK #governments second 5-year anti-AMR action plan, “Confronting #AntimicrobialResistance 2024-2029, that was launched last week. It is rich in rhetoric and pac

Wise strategies in uro-oncology presented at EAU 24

The case for widening the #intravesical approach to #bladder diseases and disorders In the European Association of #Urology 2024 conference, intravesical chemotherapy “took centre stage:” https://www.

Comments


bottom of page